G. Love & Special Sauce Announces New Festival With Citizen Cope, Ripe, & More

first_imgGarrett Dutton aka “G.Love” of G. Love & Special Sauce has announced the inaugural Cape Cod Roots & Blues Festival coinciding in celebration of the band’s 25th anniversary. The one-day event is scheduled for September 15th, 2018, and will take place along the beautiful shores of Nauset Beach in the town of Orleans, MA. Headliners G. Love & Special Sauce will be joined by singer-songwriter Citizen Cope, soulful Hawaiian outfit Ron Artis II and The Truth, and Boston Funk Ambassadors Ripe.Cape Cod Roots & Blues Festival is a celebration of family, live music, community, and the natural environment of Cape Cod. This 10-mile stretch of sandy beach offers swimming and fishing, plus surfing in non-protected areas. Dutton explains that “Orleans, Massachusetts has been our home for seven years now and we have fallen completely in love with the town, the people, and the beautiful pristine nature which surrounds the Cape. From surfing to paddle boarding, fishing and bird watching, hiking, biking, eating, drinking–the Cape has it all.”The event, curated by Dutton, features bands and performers that have personally resonated with him musically. The festival is about “bringing to the stage a musical family that we have been cultivating for 25 years strong,” he says. Local Orleans resident Mike McNamara, owner and co-founder of The Hog Island Beer Co, has been an essential proponent of the Cape Cod Roots & Blues Festival. As the exclusive beer provider for the festival, Hog Island Beer Co will create a beer garden for guests to sip craft beers and enjoy the event’s natural beauty. See what’s on tap here.For more information on the Cape Cod Roots & Blues Festival or to purchase tickets, head here.last_img read more

20 Songs That Are Perfect For 4/20

first_imgHappy 4/20! What better way to celebrate the holiday than with 20 thematically-appropriate tunes, hand selected by the L4LM crew. From blues to hip hop to reggae to funk, musicians are no strangers to the “Wildwood Weed.” So sit back, roll up a joint, and enjoy some great tunes.1. Bob Dylan – “Rainy Day Women #12 and 35”This delightfully bawdy Dylan tune is an ode to “Rainy Day Women,” a not-so-subtle pseudonym for joints. It would be more subtle, were it not for the song’s chorus, “Everybody Must Get Stoned!”2. Phish – “Makisupa Policeman”This particular version of the oft-marijuana themed Phish tune is a fan favorite. On August 17, 2011 at the UIC Pavilion, the group made some eye-roll-worthy marijuana puns on artist names, including “Dank Sinatra” and “Harry Chronic Jr.” Enjoy!3. Grateful Dead – “High Time”We could have us a high time, living the good life. 4. Peter Tosh – “Legalize It”There’s no denying what Tosh wants legalized…5. Yonder Mountain String Band – “Two Hits And The Joint Turned Brown”The John Hartford classic gets a whole new twist from Yonder Mountain String Band…6. Traffic – “Light Up Or Leave Me Alone”We think the ultimatum of this classic Traffic song pretty much speaks for itself.7. Ray Charles – “Let’s Go Get Stoned”Another essential 4/20 tune that actually hit #1 on the R&B charts when it debuted in 1966. 8. Sublime – “Smoke Two Joints”She was living in a single room with three other individuals, one of them was a male, and the other two, well the other two were females. God only knows what they were up to in there, and furthermore Susan, I wouldn’t be the least bit surprised to learn that all four of them habitually smoked marijuana cigarettes….. reefers.9. Galactic – “Sweet Leaf”This Black Sabbath ode to the green gets the funk treatment from the NOLA royalty themselves, Galactic.10. The Beatles – “Got To Get You In My Life”Commonly assumed to be a love song, this Paul McCartney original was actually written as an ode to marijuana. The band had recently been introduced to the drug by Bob Dylan, opening up their songwriting and studio experimentation tremendously in the mid-1960s. A later quote from Macca in his 1997 biography: “‘Got to Get You into My Life’ was one I wrote when I had first been introduced to pot … So [it’s] really a song about that, it’s not to a person.”11. Peter, Paul, and Mary – “Puff the Magic Dragon”Are you a pothead, Fokker?12. Cypress Hill – “Hits From The Bong”Too many Cypress Hill songs to choose from.13. Phish with Primus’ Les Claypool and Larry LaLonde – “Harpua” > “Wildwood Weed” > “Harpua”On December 6, 1996, Phish were joined by Primus’ Les Claypool and Larry LaLonde for a particularly entertaining “Harpua” in Vegas. The band segued from “Harpua” into “Wildwood Weed,” sung by Claypool, loosely based on the original Jim Stafford country tune. There were so many songs to choose from… which 4/20 favorites of yours didn’t make the list? 14. Ben Harper – “Burn One Down”Now that Ben Harper & The Innocent Criminals have reunited, we’re hoping to catch this 1995 hit at some summer festival sets.15. Dr. Dre ft. Snoop Dogg – “The Next Episode”Smoke weed every day.16. People Under The Stairs – “Acid Raindrops”Just a great, great song about Mary Jane.17. Rick James – “Mary Jane”One of the most sampled 70’s electrofunk tracks is this ballad to marijuana from Rick James.18. Afroman – “Because I Got High”Despite the artist’s recent on-stage altercation, there’s no denying that this is one of the most iconic marijuana songs. La da da da da da…19. Willie Nelson ft. Kris Kristofferson, Jamey Johnson, Snoop Dogg – “Roll Me Up And Smoke Me When I Die”Released on 4/20 in 2012, this relatively newer song written by Willie Nelson features vocals from Kris Kristofferson, Jamey Johnson, and Snoop Dogg. 20. Bob Marley – “Easy Skanking”Excuse me while I light my spliff…last_img read more

Poor sleep could clog your arteries A mouse study shows how that

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Country By Kelly ServickFeb. 13, 2019 , 1:40 PM Email Click to view the privacy policy. Required fields are indicated by an asterisk (*) C. S. McAlpine, et. al. Nature 10.1038 (2019) Poor sleep could clog your arteries. A mouse study shows how that might happencenter_img Rough sleep is bad for your mind—and your heart. It can increase the risk of clogged arteries, which can lead to stroke or heart attacks. But how these two things are connected has been a mystery. Now, a study in mice reveals a link, based on signals the brain sends to bone marrow. If the story holds true in humans, the mechanism could help explain the connection between sleep and other conditions, from obesity to cancer.  “Not everyone who is sleep-deprived develops cardiovascular disease,” says Namni Goel, a behavioral neuroscientist at the University of Pennsylvania Perelman School of Medicine in Philadelphia who was not involved in the work. The new mouse work “opens the door for human studies” that could sort out who is most at risk.In many forms of cardiovascular disease, fatty deposits build up on artery walls (a condition called atherosclerosis) and can rupture to cause a stroke or heart attack. Immune cells—in particular, white blood cells called monocytes—also play a key role. They flock to sites where these deposits have damaged blood vessels and they spawn cells that can contribute to the growing plaque. To follow up on the known connection between sleep and heart disease, immunologist Filip Swirski of Harvard Medical School and Massachusetts General Hospital in Boston wanted to explore whether sleep somehow triggered an immune process that spurs this dangerous buildup. The aortas of mice with interrupted sleep (right image) showed more plaque buildup (red) than those of mice that slept undisturbed. He and his colleagues studied mice that were genetically prone to arterial plaques. To disrupt sleep, they put a mouse in a cage where a metal bar periodically slid across the floor during the 12 daytime hours when mice normally rest. Every 2 minutes, the mouse would feel the nudge of the moving bar and wake up to step over it. While that sounds pretty miserable, Swirski notes that this is one of the least stressful sleep-interrupting techniques the field has dreamed up. (Others have sent mice plunging into water when they nod off.) He thinks of the setup in the experiments as “akin to constantly waking because there’s a little baby in the house.” desvitlab/shutterstock.com Compared with sound-sleeping counterparts, mice that underwent 12 weeks of this fragmented sleep had both larger plaques in their arteries and higher levels of two kinds of white blood cells—monocytes and neutrophils—in their blood. The researchers found that these excess immune cells were produced by stem cells in the bone marrow, but they didn’t know what was making those stem cells so active.So the scientists looked to the hypothalamus, a part of the brain involved in regulating wakefulness. A signaling molecule the hypothalamus produces called hypocretin was decreased in the brains of mice with chronically poor sleep. Discovered in 1998 as a stimulator of appetite, hypocretin also promotes wakefulness, and the neurons that make it are deficient in the brains of people with narcolepsy. Swirski’s team found that other mice that were genetically unable to make hypocretin also had more immune cells in their blood, which suggested hypocretin might be an important brake on immune cell production.The researchers then searched mouse bone marrow for cells with a receptor for hypocretin on their surface. The hypocretin-sensitive cells, they discovered, were a subset of white blood cells. And hypocretin appeared to restrict their production of a growth-promoting protein that prompts bone marrow stem cells to make more immune cells. Depleting hypocretin took the brakes off the production of immune cells that would end up in the bloodstream and further clog arteries, the team reports online today in Nature.Why would the body have this kind of brain-bone signaling? Making immune cells costs energy, and in waking hours, an animal needs that energy for other activities, Swirski speculates. So hypocretin, in addition to promoting wakefulness, also tells bone marrow cells, “Hold off—we’re busy with other stuff.” When mice are repeatedly roused, it seems, these hypocretinmaking neurons worked overtime until they got overtaxed.This might not be the only mechanism linking sleep and vascular disease. But it could help explain the increased risk observed in humans, says José Ordovás, a geneticist at Tufts University in Boston whose team recently found that people getting poor or shortened sleep were more likely to develop atherosclerosis, even after controlling for risk factors such as obesity and high blood pressure.Swirski’s team could prevent the effects of poor sleep on plaque by injecting the mice with extra hypocretin. Few scientists are ready to suggest based on mouse data alone that dosing people with hypocretin—a molecule with many complicated regulatory roles in the body—would be a good treatment for atherosclerosis. But the study does suggest that a drug that blocks hypocretin receptors—such as the insomnia treatment suvorexant, which the Food and Drug Administration approved in 2014—could raise the risk of cardiovascular disease, two Columbia University physicians, atherosclerosis researcher Alan Tall and sleep specialist Sanja Jelic, write in a commentary to be published alongside the paper.“The connection they’re making is very impressive,” neuroscientist Asya Rolls of the Technion-Israel Institute of Technology in Haifa says of the study. There’s no guarantee that humans have an identical system, and it’s very hard to make comparisons between mouse and human sleep, she notes. But she suspects that the pathway this group uncovered “is affecting much more than atherosclerosis.” For example, previous work has shown that fragmented sleep can boost tumor growth. “Once you start … to affect immunity, you are opening many other conditions that might be explained,” she says.last_img read more